ZO Radical Night Repair

High-Potency 1% Retinol Night Treatment for Advanced Skin Renewal

ZO Radical Night Repair is a physician-grade overnight treatment featuring 1% retinol combined with powerful peptides and antioxidants. This intensive formula works while you sleep to accelerate cellular turnover, reduce hyperpigmentation, smooth texture, and restore a more youthful, radiant complexion—delivering transformative anti-aging results.

Key Benefits

• Accelerates cellular turnover and renewal - Promotes rapid exfoliation of damaged surface cells to reveal fresh, healthy skin
• Reduces hyperpigmentation and dark spots - Fades age spots, sun damage, and post-inflammatory marks for even tone
• Smooths fine lines and wrinkles - Stimulates collagen production to diminish visible signs of aging
• Improves skin texture and tone - Refines rough, uneven texture for smoother, more radiant skin
• Enhances skin firmness - Strengthens skin structure and improves elasticity
• Minimizes pore appearance - Refines enlarged pores through improved cellular function
• Supports DNA repair - Helps reverse environmental damage at the cellular level

Who Should Use This Product

Radical Night Repair is ideal for:

• Experienced retinol users seeking high-potency results
• Mature skin with visible signs of aging (lines, wrinkles, loss of firmness)
• Hyperpigmentation, sun damage, or uneven skin tone
• Rough, uneven texture or enlarged pores
• Those committed to comprehensive anti-aging protocols
• Clients who have built tolerance to lower-strength retinol products
• Anyone seeking maximum overnight skin renewal

How to Use

Evening Only: After cleansing and toning, apply a pea-sized amount to face, neck, and décolleté. Avoid eye area. Use 2-3 times per week initially, gradually increasing to nightly as tolerated. Always use broad-spectrum SPF 30 or higher during the day.

Important Usage Guidelines:

• Start gradually: Begin with 2-3 nights per week, allowing skin to build tolerance
• Retinization period: Expect mild dryness, flaking, or redness during first 2-4 weeks—this is normal
• Support your barrier: Use ZO Hydrating Crème or Recovery Crème to minimize irritation
• Sun protection is essential: Retinol increases sun sensitivity; SPF is non-negotiable
• Avoid during pregnancy/nursing: Consult your physician before use
• Don't mix with acids: Avoid using with AHAs/BHAs on the same evening

Clinical-Grade Active Ingredients

Formulated with ZO's advanced retinol delivery system:

• 1% Retinol - High-potency vitamin A that accelerates cellular turnover, stimulates collagen production, and reduces hyperpigmentation. This concentration delivers professional-strength results
• Palmitoyl Tripeptide-1 & Palmitoyl Tetrapeptide-7 (Matrixyl 3000) - Peptide complex that stimulates collagen and elastin synthesis, reducing wrinkles and improving firmness
• Ascorbyl Palmitate (Vitamin C Ester) - Stable antioxidant that brightens skin and enhances retinol efficacy
• Tocopheryl Acetate (Vitamin E) - Powerful antioxidant that protects against free radical damage and supports healing
• Retinyl Palmitate - Gentle form of vitamin A that provides additional anti-aging benefits
• Beta-Glucan - Soothes inflammation and supports barrier function during retinol treatment
• Bisabolol - Natural anti-irritant that calms and soothes skin
• Encapsulated Delivery System - Time-release technology that delivers retinol gradually for enhanced tolerance and sustained efficacy

The Science of High-Potency Retinol

Retinol is the gold standard in anti-aging skincare, backed by decades of clinical research. At 1% concentration, Radical Night Repair delivers professional-strength results by binding to cellular receptors that regulate gene expression. This triggers increased collagen production, accelerated cellular turnover, normalized melanin production, and improved skin structure—resulting in visibly younger, healthier-looking skin.

Understanding Retinol Strength

ZO offers retinol products at various strengths to match your tolerance and goals:

• 0.25% - 0.5%: Gentle introduction for retinol beginners
• 1% (Radical Night Repair): High-potency for experienced users seeking maximum results
• Wrinkle + Texture Repair: Highest concentration for advanced protocols

Why Choose ZO Skin Health

Developed by world-renowned dermatologist Dr. Zein Obagi, ZO Skin Health represents the pinnacle of medical-grade skincare. Each retinol product features advanced delivery systems and supporting ingredients to maximize efficacy while minimizing irritation—delivering transformative results that over-the-counter products cannot match.

Product Details

• Size: 50 mL / 1.7 Fl. Oz.
• 1% retinol concentration - professional strength
• Encapsulated time-release delivery system
• Suitable for experienced retinol users
• Lightweight, fast-absorbing texture
• Fragrance-free formula
• Physician-grade skincare

Expected Results

Weeks 1-4: Retinization period—expect mild flaking, dryness, or redness as skin adjusts. This is temporary and indicates the product is working.

Weeks 4-8: Skin texture begins to smooth, tone becomes more even, and radiance improves.

Weeks 8-12: Visible reduction in fine lines, wrinkles, and hyperpigmentation. Skin appears firmer and more youthful.

3+ months: Continued improvements in all signs of aging with sustained use. Optimal results achieved as part of comprehensive ZO protocol.

Perfect Pairings

Maximize your retinol results by combining Radical Night Repair with:

• ZO Gentle Cleanser or Hydrating Cleanser - Gentle cleansing that won't compromise barrier
• ZO Exfoliating Polish - Use 2-3x weekly on non-retinol nights for enhanced exfoliation
• ZO Daily Power Defense - Morning antioxidant protection and DNA repair
• ZO Hydrating Crème or Recovery Crème - Essential moisture support during retinol treatment
• ZO Broad Spectrum SPF 50 - Non-negotiable daytime protection
• ZO Growth Factor Serum - Apply before retinol for enhanced anti-aging benefits

Professional Treatment Integration

Radical Night Repair enhances results from:

• Chemical peels - Use after skin has healed to maintain results
• Laser treatments - Supports collagen remodeling and healing
• Microneedling - Enhances cellular renewal and collagen production
• Injectables - Improves overall skin quality for better aesthetic outcomes

Managing Retinization

If you experience excessive dryness or irritation:

• Reduce frequency to every 2-3 nights
• Apply moisturizer first, then retinol (buffering technique)
• Use a richer moisturizer like ZO Recovery Crème
• Avoid other active ingredients temporarily
• Contact our team for personalized guidance

Available exclusively through authorized medical professionals. At Merrion Medical Aesthetics, we provide personalized retinol protocols tailored to your skin's tolerance and goals, ensuring optimal results with minimal irritation. Schedule a consultation to determine if Radical Night Repair is right for you.